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Due to the high concentration of GSH in the cells, NO rapidly reacts with the cysteine thiol group of GSH to form S-nitrosoglutatione (GSNO)

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Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4

In addition, free radicals are formed with the participation of NADPH-oxidase, NO-synthases, xanthine oxidase, cytochrome p450, aldehyde dehydrogenase, hemoproteins, etc