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The lack of sunlight, shorter days, and the tendency to stay indoors more often can all contribute to whats commonly known as the winter blues. One key factor that can significantly impact our physical and mental health during this time is the amount of essential vitamins were getting, especially Vitamin B12

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The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

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