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Together, these findings reveal a remarkable complexity and sophistication of enteric neural regulation of sensory, motor, and secretory function of the gut involving distinct populations of macrophages interacting with intrinsic and extrinsic nerves and nonneuronal elements (enteric glia, PDFGR cells, and interstitial cells of Cajal) of the ENS, modulated by the gut microbiota

Neuron 101, 10701088

Mechanistic studies suggest that FMT works by reducing systemic inflammation and suppressing the lipopolysaccharide-TLR4 signalling pathway, which plays a key role in the inflammatory response in PD[218]

Even small differences in these factors can affect how a peptide dissolves and behaves in solution