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Meanwhile, seroconversion of anti-double-stranded DNA antibodies appear in these patients (anti-dsDNA decreased from 157 IU/L to 12 IU/L (P = 0.03)).These findings suggest that daratumumab could offer new possibilities for managing resistant lupus nephritis LN ( Lennard Ostendorf and colleagues administered daratumumab to address severe and life-threatening cases of systemic lupus erythematosus (SLE) in two patients

It is thought that the first organ that becomes susceptible to autoimmune damage is the weakest link, where the person has a genetic predisposition or the organ has become damaged

Chandy posits a similar mechanism at play, suggesting that the swift reparative actions of B12 injections could momentarily overwhelm the body, leading to a temporary intensification of symptoms

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