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Surprisingly, selenium supplementation was found to be ineffective for individuals with low selenium levels, whereas it was associated with an elevated risk of high-grade prostate cancer in those with high selenium levels

Both CBS OPT and L2HGDH OPT are about 7KDa larger than the endogenous ones

Amino acid metabolism in mammalian cell cultures

Matayatsuk C, Poljak A, Bustamante S, Smythe GA, Kalpravidh RW, Sirankapracha P, et al