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Ferroptotic foam cells release substantial inflammatory mediators, including IL-1 and IL-18, which belong to the IL-1 cytokine family and undergo caspase-1-mediated activation ( B pathway in CHD

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al

doi: 10.1016/j.aca.2011.02.017

FPS-ZM1, recognized as an inhibitor of the receptor for advanced glycation end products (RAGE), exhibited the capability to reduce the overproduction of IL-1, IL-6, TNF-, and cyclooxygenase-2 (COX-2) induced by LPS, both in BV-2 cells and primary microglial cells
