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To summarize, 2D cell models of cell lines are the easiest to handle and most reproducible models for in vitro toxico-metabolomic studies

Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus

Seven pivotal studies utilizing this model have demonstrated the multifaceted neuroprotective effects of natural products, as detailed below (Table 9)

Crowther RR, Qualls JE
