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Standardization of Senescence Biomarkers: A major challenge in both the development and application of senescence-targeting therapies is the identification of reliable biomarkers that can accurately assess the presence of senescent cells and their effects.256 Current biomarkers for senescence, such as p16^INK4a, -galactosidase activity, and SASP factors, are useful in research settings, but their clinical applicability remains limited

This is attributed to the heightened levels of NNMT potentially rendering NAM irretrievable, thereby constraining NAD + -dependent processes (Trammell and Brenner, 2015)

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