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Besides, there are also studies based on the integrated analysis of 1 H nuclear magnetic resonance metabolomics and dynamic 13 C isotope tracer technology showing that FGF-21 intervention effectively remodeled glucose metabolism in the brain, facilitating the conversion of [ 113 C]-glucose to the key neurotransmitter precursor and energy metabolism intermediate [ 313 C]-lactate while restoring metabolic homeostasis to the -aminobutyric acidergic system [219]

Jung, T

doi: 10.1530/JOE-17-0542 47

This conclusion is further supported by the observation that mice lacking Epac1 , which encodes one of the two isoforms of EPAC in mammals, are more resistant to DIO and have improved glucose tolerance and heightened central leptin sensitivity, as measured through STAT3 activation, compared with control mice 98