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Concurrently, oxidative stress is significantly increased during inflammation, and upregulated NOX1 expression in microglia increases reactive oxygen species (ROS) levels, thereby exacerbating glutamate neurotoxicity and ultimately worsening neuronal damage [300, 301, 309]

Integrative Modeling of Oxidative Stress and C1 Metabolism Reveals Upregulation of Formaldehyde and Downregulation of Glutathione 1

At 150 keV, the tumor region exhibited a high CT signal, with a recorded CT value of 368.66 HU, and this elevated signal intensity was maintained as the X-ray energy increased (Figure S5B)

Studies have shown that ID weakens the response to these therapies, making patients more susceptible to complications such as fatigue, immunosuppression, and anemia