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Therefore, the limited protective effect of GPX4 against keratinocyte ferroptotic cell death could be associated with the disruption of the GPX4 function by oxidative damage after multiple UVB radiation

In the absence of targeted pharmacological interventions for specific aldehyde types, the core of any treatment plan necessitates the continuous use of one or more strong sulfur-containing antioxidants, such as NAC, taurine, GSH, and lipoic acid, to react with and neutralize the accumulated aldehydes before additional cellular damage occurs

Mononuclear cells were isolated by Ficoll-Hypaque centrifugation using standard procedures

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