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Supplementary Video 9 (download MP4 Conformational changes at the NBSs of CydD and CydC when the lateral membrane gate closes, and conformational coupling to the NBDs

This disruption of the normal equilibrium between hepatocyte and its microenvironment (i.e., in particular with Kupffer cells and hepatic stellate cells, the latter promoting fibrogenesis) seems to determine the degree of hepatocyte injury and the triggering of downstream pathways that lead to cirrhosis, as reviewed in-depth elsewhere (70)

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c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses