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It is the only one with decades of clinical research behind it
94,292,328330 However, when hypoxia is prolonged, there is an up-regulation of natural antisense HIF-1 that decreases HIF-1 expression by destabilizing its mRNA

By repairing the damaged environment, it creates a healthier home for your microbiome to balance itself naturally, but it doesn't actively shift the bacteria on its own

Psychiatry 37:e101374
