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The renin-angiotensin system (RAS) comprises the classic arms, which include the angiotensin (Ang) II/angiotensin-converting enzyme (ACE)/Ang II type 1 receptor (AT 1 R) axis associated with blood pressure elevation and organ damage, and the protective arms, involving Ang (1-7)/ACE2/Mas axis, which offers organ-protective effects [2]

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Peptides with fewer residues are more susceptible to rapid enzymatic degradation, leading to shorter systemic exposure. Fosgerau & Hoffmann, Drug Discovery Today Half-Life Each peptide has a defined biological half-life the time it takes for half of the substance to be eliminated from the bloodstream

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