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Funding This study was supported by the Special Project for Applied Technology Research and Development and Sustainable Development Agenda Innovation Demonstration Zone of Chengde City, Hebei Province (202502B046)

KPV, the C-terminal tripeptide of -MSH (Lys-Pro-Val), has been investigated for its interaction with NF-B signaling, with researchers observing inhibition of NF-B nuclear translocation and downstream inflammatory cytokine expression (TNF-, IL-6, IL-8) in cell culture models

Flow cytometric quantification of DCFH-DA fluorescence confirmed acute ROS increased exclusively in ChaC1/AUR co-treated HCC cells, but absent in catalytically inactive ChaC1-Mut/AUR co-treated and control cells (Fig

T1 targets immune balance, while nesfatin-1 links metabolic state and anxiety