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The World Anti-Doping Agency

and subsequent investigators has characterised GHK-Cu as a potent activator of wound-healing cascades, upregulating transforming growth factor- (TGF-) and suppressing inflammatory mediators such as TNF- and IL-6 in pre-clinical models

This will allow the selective and effective localization of drugs at predefined targets (e.g., overexpressed receptors in cancer) while restricting its access to normal cell thus maximizing therapeutic index and reducing toxicity

Due to the risk of hypoglycemia, the initial treatment doses of insulin administered simultaneously with pramlintide must be lowered by 50% or more [59]