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10.1093/eurheartj/ehv561 9 BorlaugB
Similarly, in the cortex of wobbler mouse model of ALS, reduced GABA mediated inhibition in the layer 5 pyramidal neurons as a result of loss of GABAergic interneurons was shown, resulting in cortical excitability (Nieto-Gonzalez et al., 2011)
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In general, CoQ10 deficiency can be divided into primary, resulting from genetic defects in the multistep CoQ10 biosynthesis pathway, and secondary effects, associated with other diseases, such as cardiovascular disease, type II diabetes, or liver disease [27]
