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Toxicol.Mech.Methods 2008;18(6):455-462

Specific substrate binding is enabled by Arg 166 , Arg 284 and Ser 447 while dual cofactor specificity for NAD + and NADP + is mediated by Asn 184

BARNETT et al, 1994 OHTANI et al, 1984 BRASS, 2000 MILLINGTON et al, 1993 HEINONEN, 1996

discussed glutathione synthesis as a key determinant in mitigating cuproptosis and disulfidptosis, two novel, metal-dependent cell death pathways exacerbated in sepsis
