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4.5 Intranasal administration Drugs delivered to the olfactory region via IN can reach the olfactory bulb and other CNS regions within minutes via intracellular and extracellular pathways along the olfactory nerves or diffusion (especially for lipophilic small molecules), allowing for a higher concentration of the therapeutic agents in the brain compared to the bloodstream

The processed data matrix was exported as a.csv file and analyzed using Metaboanalyst 6.0v( Statistical analysis Clinical severity was assessed using CARS scores obtained at baseline and after completion of the three-month GF-MKD intervention

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