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Therefore, it is speculated to be a multi-factorial disorder, involving epigenetics, genetics, and environmental factors
However, the protective effects of AHR activation must be balanced against the antagonistic IL-13/IL-4JAKSTAT6/STAT3 signaling pathway, which disrupts barrier integrity and promotes oxidative stress in AD
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Most of the current methods designed to detect reactive cysteines and redox PTMs are indirect and are based on the differential alkylation of reduced and oxidized thiols ( Figure 2 )
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