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The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO), registration number: CRD42024554513 (Available from) ( 2.2 PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

If you consider discontinuing the shots because your daily B12 injections arent working, or because chronic fatigue is still bothering you, it might be that you havent given them enough time to work
LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

The most consequential decision in any stacking protocol isn't which compounds to combine
