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On the ROS source side, NOX isoform modulation (isoform-selective inhibitors or genetic silencing) dampens pathological microdomain fluxes while preserving host defense and organelle-targeted approaches (e.g., reinforcing mitochondrial quality controlbiogenesis/mitophagy, precise control of Ca handling and RETrather than blanket scavenging) recalibrate matrix and IMS redox (Altenhfer et al