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Cytokines modulate steroidogenesis and can skew estrogen-progesterone ratios, which changes menstrual flow, length, and symptom burden

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This metabolite can accumulate to high levels when -ECS is overexpressed alone, either in the cytosol or the chloroplast (Noctor et al., 1996, 1998a

For example, luteolin is effective in therapeutically induced cytotoxicity of cancer cells due to its suppression of cell survival pathways, such as phosphatidylinositol-3-kinase (PI3K)/Akt, NF-B, and X-linked inhibitor of apoptosis protein (XIAP), resulting in the stimulation of apoptosis pathways, including the induction of the p53 tumour suppressor [39]