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Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

For endotoxin-sensitive assays, endotoxin testing or appropriate controls may be necessary to avoid attributing contaminant-driven effects to the peptide itself

Research also suggests significant benefits for gut health, inflammatory modulation, and angiogenesis