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Pathways regulating ferroptosis in AD Kelch-like ECH-associated protein 1 (Keap1)/Nrf2)/antioxidant response element (ARE) pathway In cellular defense against oxidative stress, the Keap1/Nrf2/ARE signaling pathway regulates the expression of various proteins involved in detoxification and antioxidant defense, positioning it as a potential target for AD treatment (61)

Our findings in brain organoids with PSEN1 mutation complement well the results in human cortical organoids challenged with A that showed an increased expression of ferroptosis-promoting factors like Phkg243, Txnrd144 and Pparg42 [50]

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