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The relative importance of the three enzymes appears to be related to the H 2 O 2 levels in the RBC [59]
The aforementioned activation may consequently result in the release of substance P, neurokinin A, or calcitonin gene-related peptide (CGRP) [16]
In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]
