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Baseline serum B12, methylmalonic acid (MMA), and homocysteine levels help guide initial dosing and expected response timelines

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Polyphenols (flavonoids, phenolic acids) and carotenoids contribute to redox/inflammatory control, with plausible higher functional relevance luteally (increased ROS), but total flavonoid intake shows limited associations with E2, P4, or prolactin in premenopausal women, though low carotenoid status links to irregularity (OR 1.21.5) [167]