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Instead, we utilised the high nucleophilic reactivity of RSS and RS(S) n S (due to their low pK a and the -effect of the non-terminal sulfur atom) that enables reaction with iodoacetamide (IAM) to generate reaction products that incorporate the terminal sulfane sulfur (Fig

If the product used in these NTP studies was indeed kava root powder, the results need to be interpreted again with caution because the powder, administered whole and directly to the rodents, is substantially different from the traditional and anxiolytic kava forms that humans use

Soppert et al., 2020)
