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Furthermore, GSH cannot cross cell membranes, but first needs to be broken down into its constituent amino acids and then re-synthesised inside the cell

CrossRef Targetting PED/PEA-15 for diabetes treatment Francesca Fiory, Rosa Spinelli, Gregory Alexander Raciti, Luca Parrillo, Vittoria Desposito, Pietro Formisano, Claudia Miele, Francesco Beguinot Expert Opinion on Therapeutic Targets.2017

These include reduced expression of cereblon, or other proteins involved in the UPS, genetic alterations including mutations, deletions or alternative splice variants, and upregulation of drug efflux pump(s)

Among the peptide GLP-1R agonists are semaglutide and liraglutide, which are widely used in the treatment of obesity