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Nevertheless, the direct mechanism of MSCs targeting cuproptosis is novel and needs further exploration since cuproptosis may be implicated in the pathogenesis of IBD

Biochem Biophys Res Commun 417:653658 Ferreira DW, Naquet P, Manautou JE (2015) Influence of vanin-1 and catalytic products in liver during normal and oxidative stress conditions

Pre-existing conditions can change the risk-benefit calculation

PMC6073405 BPC-157 angiogenic signaling VEGFR2AkteNOS activation, nitric oxide bioavailability, FAK-paxillin cell-anchoring cascade, anti-cytokine modulation: PMC8275860 TB-4 / TB-500 G-actin sequestration and threshold-saturation mechanism actin-monomer binding, cytoskeletal mobilization for cell migration, mass-action pharmacodynamics requiring bolus dosing: PubMed 12581423 TB-4 Ac-SDKP anti-fibrotic fragment N-terminal tetrapeptide (fragment 14) released by meprin- and POP processing