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We follow [30, 31] and use a reversible bi-reactant Michaelis-Menten mechanism

Biological Mechanisms of Therapeutic Peptides Receptor Binding and Signal Transduction Most therapeutic peptides function through specific binding to cell surface or intracellular receptors

doi: 10.1016/j.arcmed.2017.11.004

It is important to note that there is a much higher chance that the false negative model predictions would be uncomplicated appendicitis cases, as evident from very high sensitivity in the case of gangrenous appendicitis detection (99.96%)
