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Iodoacetamide was added to 10 mM and incubated in the dark at room temperature for 30 min to alkylate the proteins

There are two main types of fatty liver disease: Nonalcoholic fatty liver disease (NAFLD) : This type affects 1 in 3 adults in the U.S

Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2

In other experiments and supporting previous findings obtained in murine macrophages 31 , we observed that also type II IFN/IFN remarkably enhances the production of IL-6 by neutrophils incubated with R848