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Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation
PGs are synthesized upon oxidation of arachidonic acid (AA) by PTGS enzymes that contain both the cyclooxygenase and peroxidase functions
Rather than canonically activating downstream proinflammatory cytokines, STING promotes autophagic degradation of GPX4, thereby triggering neuronal ferroptosis (Woo et al., 2024)
