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Pipeline of obesity pharmacotherapies GLP-1 receptor agonists GLP-1 RA increase satiety, reduce food intake and delay gastric emptying whilst they also stimulate insulin release and inhibit glucagon secretion in a glucose-dependent manner (Fig
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This coincided with an upregulation of the PI3K pathway, 61 and a 29 and 66% increase of Akt expression in MDA-MB-468 breast and SW480 colon cancer cell lines, respectively
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