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Consequently, this work focused on elucidating the APP-serum interactions and the underlying mechanisms

Nature (2014) 510:298302

1 Introduction According to the 2022 World Alzheimer's Disease Report, more than 550 million people worldwide suffer from Alzheimer's disease (AD) or related conditions (Serge Gauthier et al., 2022)

The fetal liver exhibited higher mitochondrial activity and increased mitochondrial DNA copy numbersboth indicative of enhanced energy metabolismwithout major shifts in gene expression, suggesting that regulation may occur at the protein level (Safain et al., 2025)
