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We elucidate how IGF-1 may be involved in molecular signaling defects that occurs in MetS-related neurodegenerative disorders and highlight the importance of IGF-1 as a potential therapeutic target in MetS-related neurological diseases

Caffeine, GSH, dithionitrobenzene (DTNB), AsA, metaphosphoric acid, caffeine, and pyrocatechol were purchased from Wako Pure Chemical Industries, Ltd

For example, ginsenosides has been shown to increase GPX, SOD and catalase (CAT) activity and restore GSH levels, while inhibiting ERK and JNK MAPK pathways (Park et al., 2012

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