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This conclusion can explain why phase III clinical trials in patients with advanced breast cancer involving sunitinib or bevacizumab as anti-angiogenic agent, either alone or with chemotherapy, have not been as successful as expected

Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR: Role of NRF2 in protection against hyperoxic lung injury in mice

Panel C of Figure 5 shows that the velocity of the CBS reaction tracks the methionine input as expected, but that the velocity of the GS reaction by which GSH is synthesized has milder fluctuations