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Nanoparticulate drug delivery systems have shown important advantages in stability and bioavailability, such as: protection of the drug from premature degradation and interaction with the physiological environment increased intracellular penetration increased solubility of insoluble drugs enhanced drug absorption [3] Smaller particles have larger surface area, which improves bioavailability The research has shown that smaller particles, preferably of 100 nm [4], significantly improve the bioavailability of the drug

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Some individuals might experience gastrointestinal discomfort, such as bloating or abdominal pain