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Many users find that metabolic improvements persist for 2-4 weeks after discontinuing treatment, suggesting lasting changes in cellular function

These cells have a defect in OXPHOS and rely on oxidative glutamine-glutamate-alpha-ketoglutarate metabolism for survival (Figure 2)

And, by the time the patient awakes in the morning, the blood levels could be expected to have fallen more than they would have had the patient taken the drug at bedtime

A single 100,000 IU injection can elevate serum 25-hydroxyvitamin D within four weeks and sustain sufficiency for up to three months, although individual kinetics vary with baseline depletion and body composition