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Materials and methods Institutional Review Board approval was obtained at the University of Washington for this single-center study of 15 participants with mid-stage PD

This has been observed in the form of elevated body temperature, particularly at night 13,14,15,16 , when thermoregulatory cooling responses are critical for sleep onset and quality 17,18
doi: 10.1126/science.290.5489.147 254 WongL

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