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IGF-1R deficiency in Apoe -/- mice macrophages increases atherosclerotic extensiveness and destabilizes plaque stability by lowering SMCs and collagen content, according to the pleiotropic effects of IGF-1 on various vascular wall cells (119)

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NNMT is elevated with expression of ZEB1, a specific CSC transcription factor, but not all NNMT-positive cells are associated with ZEB1 overexpression
