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Their expression is tissue-dependent, whereas GPx1 is found in red cells, liver, lung, and kidney, GPx2 is found in gastrointestinal tracts, GPx3 is present in different organs such as kidney, lung, epididymis, vas deferens, placenta, seminal vesicle, heart and muscle and GPx4 which is widely distributed in various tissues [30]

These studies were conducted in a mouse model of compression SCI, in which SF (5 mg/kg i.p.) was administered 1 h after injury [250], and in a rat model of contusion SCI, in which SF (5 mg/kg i.p.) was administered 15 min after injury and once daily for 3 days thereafter [249]

2i), established biomarkers of liver injury, were significantly decreased in mice overexpressing AGXT in hepatocytes

Parthasarathy, G., Revelo, X