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These pathways are commonly studied in experimental models to understand how peptide signaling influences adipocyte function and energy metabolism

Soleimannejad and colleagues reported that black cumin seed extract at 10 and 20 mg/kg improved global ischemia outcomes by a mechanism that involved an increase in gene expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1 (HIF), and matrix metallopeptidase (MMP9) [60]

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This work, together with our previous findings using the drug raloxifene, demonstrates that pharmacologically delaying SG disassembly impairs timely stress resolution and leads to increased GBM cell death