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602 The authors identified a new enzyme, TOT1, to be the responsible enzyme, using a combination of biotransformation, in vitro biochemical characterization, and computational modeling (Figure 74)

Acknowledgments NA gratefully acknowledges the partial financial supports received from FCT (Government of Portugal) through contract (SFRH/BPD/84671/2012), the Aveiro University Research Institute/CESAM (UID/AMB/50017/2013), COMPETE through Project n. FCOMP-01-0124-FEDER-02800 (FCT PTDC/AGR-PRO/4091/2012), and to FCT/MEC through national funds, and the co-funding by the FEDER, within the PT2020 Partnership Agreement and Compete 2020