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The supplement did not contain lipoic acid, and it did not affect levels of lipoic acid, so it appears that children were more likely to improve if they already had sufficient lipoic acid, whereas a lower level of lipoic acid seemed to be associated with less improvement

Arrhythmia exacerbation, chest pain (unspecified), flushing, hypotension, myocardial infarction, and vasculitis have been observed during postmarketing experience

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By using a ready-to-use strip, researchers can reduce preparation-related variability while maintaining experimental control throughout extended study timelines