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However, inhibition of PGE 2 -EP2 only reduces demyelination when started at the same time as cuprizone treatment, not when started during peak demyelination suggesting a role for PG during the initiation of demyelination (Fig

The practical approach is to reconstitute your first vial, use it through weeks 1 to 4 (drawing only 1.0 mg total), then continue into weeks 5 to 8 from the same reconstituted vial

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Consistent with this, cells limit GSSG buildup through efficient recycling and export mechanisms 8