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Variances in circadian phase, light responsiveness, and clock gene expression identified between older and younger adults [41], could lead to a different reaction to vitamin B12

Tsuduki (2018) Effects of dietary intake of Japanese mushrooms on visceral fat accumulation and gut microbiota in mice

In particular, hyperhomocysteinemia leads to quenching nitric oxide by oxidative stress and disrupts the uncoupling of nitric oxide synthase activity, leading to a reduction in nitric oxide bioavailability [72]

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