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Key challenges The lack of reliable biomarkers: Because dormant tumor cells cannot be visualized by conventional methodologies such as histopathology or standard imaging modalities, the identification and validation of robust, specific biomarkers are critical.120,166 Drug resistance: Dormant tumor cells are arrested in the G0/G1 phase of the cell cycle, and their basal metabolism is markedly reduced, allowing them to evade therapies that target proliferating cells

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A placebo-controlled double-blind randomized trial of the effect of oral supplementation with spermotrend, maca extract (lepidium meyenii) or L-carnitine in semen parameters of infertile men