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Loop 3 provides the necessary flexibility in the ABS of the bacterial GUSs to accommodate various substrates According to the enzyme-activity analysis, all GUSs accepted one or more substrates larger than 10 , but the superimpositions of Cp GUS and Rg GUS with the Bifd GUS E479A / 10 complex indicated possible steric clashes between the aglycone and loop 5 or loop 3 of Cp GUS and Rg GUS, respectively

Rights and permissions About this article Cite this article Behera, M., Kumari, N., Raza, K

While not in this study, liposomal GSH has also been found to improve glutathione levels

The druglike and orally bioavailable compounds identified herein are active in animal models of schistosomiasis with a broader range of developmental stages targeted than the drug of choice, PZQ