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Consequently, any factor inhibiting SLC7A11 function or downregulating its expression leads to intracellular GSH depletion, thereby depriving GPX4 of its essential substrate and ultimately triggering irreversible ferroptosis

These toxic metals disrupt thyroid function, deplete essential minerals like zinc and selenium, generate oxidative stress, and can directly damage hair follicle cells

The Form and Functions of teh Cell in Health and Disease (ed E

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