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Consequently, any factor inhibiting SLC7A11 function or downregulating its expression leads to intracellular GSH depletion, thereby depriving GPX4 of its essential substrate and ultimately triggering irreversible ferroptosis

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These toxic metals disrupt thyroid function, deplete essential minerals like zinc and selenium, generate oxidative stress, and can directly damage hair follicle cells

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The Form and Functions of teh Cell in Health and Disease (ed E

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